PELP1 抗体 (Internal Region)
Quick Overview for PELP1 抗体 (Internal Region) (ABIN6264131)
抗原
See all PELP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- PELP1 Antibody detects endogenous levels of total PELP1.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human PELP1, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1) (AA 1021-1180) antibody
PELP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1) (AA 1031-1180) antibodyPELP1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 2D6D11 unconjugated
anti-Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1) (AA 1031-1180) antibodyPELP1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4F1D1 unconjugated
anti-Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1) antibodyPELP1 适用: 人 WB, IHC, ELISA 宿主: 兔 Monoclonal 6H4 unconjugated Recombinant Antibody
anti-Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1) antibodyPELP1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1) (AA 744-771) antibodyPELP1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB17558 unconjugated
anti-Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1) (AA 337-410) antibodyPELP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F7 unconjugated
anti-Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1) antibodyPELP1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1) (AA 791-840) antibodyPELP1 适用: 人, 小鼠, 大鼠, 豚鼠, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1) (AA 337-410) antibodyPELP1 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 4F3 unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- PELP1 (Proline-, Glutamic Acid- and Leucine-Rich Protein 1 (PELP1))
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别名
- PELP1
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背景
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Description: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Involved in nuclear receptor signaling via its interaction with AR and NR3C1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex, the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211).
Gene: PELP1
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分子量
- 119kDa
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基因ID
- 27043
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UniProt
- Q8IZL8
抗原
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