Nth Endonuclease III-Like 1 (NTHL1) 抗体
Quick Overview for Nth Endonuclease III-Like 1 (NTHL1) 抗体 (ABIN6263755)
抗原
See all Nth Endonuclease III-Like 1 (NTHL1) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- NTHL1 Antibody detects endogenous levels of total NTHL1
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交叉反应
- 人, 小鼠
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human NTHL1
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亚型
- IgG
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应用备注
- WB 1:1000-3000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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- Nth Endonuclease III-Like 1 (NTHL1)
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别名
- NTHL1
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背景
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Description: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
Gene: NTHL1
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分子量
- 34 kDa
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基因ID
- 4913
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UniProt
- P78549
抗原
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