MARK4 抗体 (Internal Region)
Quick Overview for MARK4 抗体 (Internal Region) (ABIN6263134)
抗原
See all MARK4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- MARK4 Antibody detects endogenous levels of total MARK4.
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预测反应
- Pig,Bovine,Horse,Sheep,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human MARK4, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-MAP/microtubule Affinity-Regulating Kinase 4 (MARK4) (C-Term) antibody
Verified MARK4 适用: 人, 小鼠 ELISA, WB, FACS 宿主: 山羊 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 4 (MARK4) (Center) antibodyMARK4 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 4 (MARK4) (AA 461-510) antibodyMARK4 适用: 人, 小鼠 ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 4 (MARK4) (AA 611-641), (C-Term) antibodyMARK4 适用: 人 WB 宿主: 兔 Polyclonal RB5447 unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 4 (MARK4) (Internal Region) antibodyMARK4 适用: 人, 小鼠 IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- IF/ICC 1:100-1:500, WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- MARK4 (MAP/microtubule Affinity-Regulating Kinase 4 (MARK4))
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别名
- MARK4
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背景
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Description: Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).
Gene: MARK4
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分子量
- 82kDa
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基因ID
- 57787
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UniProt
- Q96L34
抗原
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