Necdin-Like 2 抗体 (Internal Region)
Quick Overview for Necdin-Like 2 抗体 (Internal Region) (ABIN6263079)
抗原
See all Necdin-Like 2 (NDNL2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- MAGG1 Antibody detects endogenous levels of total MAGG1.
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预测反应
- Bovine,Horse,Rabbit
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human MAGG1, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Necdin-Like 2 (NDNL2) antibody
NDNL2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Necdin-Like 2 (NDNL2) (AA 2-52) antibodyNDNL2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F7 unconjugated
anti-Necdin-Like 2 (NDNL2) (AA 215-264) antibodyNDNL2 适用: 人, 小鼠, 大鼠, 豚鼠, 马, 兔, Bat, 犬, Hamster, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Necdin-Like 2 (NDNL2) (Middle Region) antibodyNDNL2 适用: 人, 小鼠, 大鼠, 豚鼠, 马, 兔, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- Necdin-Like 2 (NDNL2)
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别名
- NSMCE3
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背景
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Description: Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity).
Gene: NSMCE3
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分子量
- 34 kDa
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基因ID
- 56160
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UniProt
- Q96MG7
抗原
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