MAGEF1 抗体 (Internal Region)
Quick Overview for MAGEF1 抗体 (Internal Region) (ABIN6263078)
抗原
See all MAGEF1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Internal Region
-
特异性
- MAGF1 Antibody detects endogenous levels of total MAGF1.
-
预测反应
- Dog
-
纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
-
免疫原
- A synthesized peptide derived from human MAGF1, corresponding to a region within the internal amino acids.
-
亚型
- IgG
-
-
anti-Melanoma Antigen Family F, 1 (MAGEF1) (AA 1-307) antibody
MAGEF1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Melanoma Antigen Family F, 1 (MAGEF1) (AA 226-275) antibodyMAGEF1 适用: 人, Cow, 犬, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Melanoma Antigen Family F, 1 (MAGEF1) (AA 274-303), (C-Term) antibodyMAGEF1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB2261 unconjugated
-
-
应用备注
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
-
有效期
- 12 months
-
-
- MAGEF1 (Melanoma Antigen Family F, 1 (MAGEF1))
-
别名
- MAGEF1
-
背景
-
Description: Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair (PubMed:29225034).
Gene: MAGEF1
-
分子量
- 35 kDa
-
基因ID
- 64110
-
UniProt
- Q9HAY2
抗原
-
