LONP1 抗体 (C-Term)
Quick Overview for LONP1 抗体 (C-Term) (ABIN6262995)
抗原
See all LONP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- LONP1 Antibody detects endogenous levels of total LONP1.
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预测反应
- Pig,Bovine,Horse,Sheep,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human LONP1, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Lon Peptidase 1, Mitochondrial (LONP1) (AA 361-460) antibody
LONP1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Lon Peptidase 1, Mitochondrial (LONP1) (AA 1-959) antibodyLONP1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Lon Peptidase 1, Mitochondrial (LONP1) (AA 120-400) antibodyLONP1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Lon Peptidase 1, Mitochondrial (LONP1) (AA 614-959) antibodyLONP1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lon Peptidase 1, Mitochondrial (LONP1) (AA 389-418) antibodyLONP1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB40823 unconjugated
anti-Lon Peptidase 1, Mitochondrial (LONP1) (AA 661-761) antibodyLONP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B2 unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- LONP1 (Lon Peptidase 1, Mitochondrial (LONP1))
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别名
- LONP1
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背景
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Description: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575).
Gene: LONP1
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分子量
- 100 kDa
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基因ID
- 9361
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UniProt
- P36776
抗原
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