LC3A / LC3B (N-Term) 抗体
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北京 101111
Quick Overview for LC3A / LC3B (N-Term) 抗体 (ABIN6262925)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- LC3A/B Antibody
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特异性
- LC3A/B Antibody detects endogenous levels of total LC3A/B.
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预测反应
- Pig,Zebrafish,Bovine,Sheep,Dog,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human LC3B, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-LC3A / LC3B (AA 31-121) antibody
适用: 人 IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-LC3A / LC3B antibody适用: 人, 大鼠 WB 宿主: 小鼠 Monoclonal 3E9-E5-C9 unconjugated
anti-LC3A / LC3B antibody适用: 人, 大鼠, 小鼠 IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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: "Human tissue kallikrein 1 ameliorates erectile function via modulation of macroautophagy in aged transgenic rats." in: Andrology, (2018) (PubMed).
: "Mycobacterium smegmatis Induces Neurite Outgrowth and Differentiation in an Autophagy-Independent Manner in PC12 and C17.2 Cells." in: Frontiers in cellular and infection microbiology, Vol. 8, pp. 201, (2018) (PubMed).
: "Inhibition of mTORC1 signaling protects kidney from irradiation-induced toxicity via accelerating recovery of renal stem-like cells." in: Stem cell research & therapy, Vol. 9, Issue 1, pp. 219, (2018) (PubMed).
: "HMGB1/RAGE axis mediates the apoptosis, invasion, autophagy, and angiogenesis of the renal cell carcinoma." in: OncoTargets and therapy, Vol. 11, pp. 4501-4510, (2018) (PubMed).
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- LC3A / LC3B
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别名
- LC3A/B
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背景
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Description: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Gene: MAP1LC3B
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分子量
- 14.16 kDa
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基因ID
- 84557, 81631
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UniProt
- Q9H492
抗原
-
