LAPTM4B 抗体 (Internal Region)
Quick Overview for LAPTM4B 抗体 (Internal Region) (ABIN6262909)
抗原
See all LAPTM4B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- LAPTM4B Antibody detects endogenous levels of total LAPTM4B.
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human LAPTM4B, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (AA 174-226) antibody
LAPTM4B 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (AA 195-209) antibodyLAPTM4B 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal RB42294 unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (Middle Region) antibodyLAPTM4B 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马, 兔, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (AA 216-265) antibodyLAPTM4B 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马, 兔, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (AA 218-317) antibodyLAPTM4B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))
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别名
- LAPTM4B
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背景
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Description: Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).
Gene: LAPTM4B
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分子量
- 24 kDa
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基因ID
- 55353
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UniProt
- Q86VI4
抗原
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