KIDINS220 抗体 (Internal Region)
Quick Overview for KIDINS220 抗体 (Internal Region) (ABIN6262800)
抗原
See all KIDINS220 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Internal Region
-
特异性
- KIDINS220 Antibody detects endogenous levels of total KIDINS220.
-
预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
-
纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
-
免疫原
- A synthesized peptide derived from human KIDINS220, corresponding to a region within the internal amino acids.
-
亚型
- IgG
-
-
anti-Kinase D-Interacting Substrate, 220kDa (KIDINS220) (C-Term) antibody
KIDINS220 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Kinase D-Interacting Substrate, 220kDa (KIDINS220) (pSer918) antibodyKIDINS220 适用: 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Kinase D-Interacting Substrate, 220kDa (KIDINS220) (AA 1335-1348), (Intracellular) antibodyKIDINS220 适用: 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
-
有效期
- 12 months
-
-
- KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))
-
别名
- KIDINS220
-
背景
-
Description: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
Gene: KIDINS220
-
分子量
- 186-197 kDa
-
基因ID
- 57498
-
UniProt
- Q9ULH0
抗原
-
