IRS4 抗体 (C-Term)
Quick Overview for IRS4 抗体 (C-Term) (ABIN6262669)
抗原
See all IRS4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- IRS4 Antibody detects endogenous levels of total IRS4.
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预测反应
- Bovine,Horse,Rabbit
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human IRS4, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Insulin Receptor Substrate 4 (IRS4) (AA 850-950) antibody
IRS4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5B9 unconjugated
anti-Insulin Receptor Substrate 4 (IRS4) (AA 633-647) antibodyVerified IRS4 适用: 小鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Insulin Receptor Substrate 4 (IRS4) (AA 401-500) antibodyIRS4 适用: 小鼠, 大鼠 IF (cc), IF (p), ELISA, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor Substrate 4 (IRS4) (AA 1-196) antibodyIRS4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor Substrate 4 (IRS4) (AA 1-299) antibodyIRS4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- IRS4 (Insulin Receptor Substrate 4 (IRS4))
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别名
- IRS4
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背景
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Description: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.
Gene: IRS4
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分子量
- 133 kDa
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基因ID
- 8471
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UniProt
- O14654
抗原
-
