HIPK2 抗体 (N-Term)
Quick Overview for HIPK2 抗体 (N-Term) (ABIN6262242)
抗原
See all HIPK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- HIPK2 Antibody detects endogenous levels of total HIPK2.
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预测反应
- Pig,Zebrafish,Bovine,Horse,Rabbit,Chicken
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human HIPK2, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-Homeodomain Interacting Protein Kinase 2 (HIPK2) (Middle Region) antibody
HIPK2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Homeodomain Interacting Protein Kinase 2 (HIPK2) (AA 961-1065) antibodyHIPK2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1F10 unconjugated
anti-Homeodomain Interacting Protein Kinase 2 (HIPK2) (AA 961-1065) antibodyHIPK2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F4 unconjugated
anti-Homeodomain Interacting Protein Kinase 2 (HIPK2) antibodyHIPK2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Homeodomain Interacting Protein Kinase 2 (HIPK2) antibodyHIPK2 适用: 人, 大鼠 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal 1F10 unconjugated
anti-Homeodomain Interacting Protein Kinase 2 (HIPK2) (AA 977-1198) antibodyHIPK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Homeodomain Interacting Protein Kinase 2 (HIPK2) (AA 816-977) antibodyHIPK2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Homeodomain Interacting Protein Kinase 2 (HIPK2) (AA 961-1065) antibodyHIPK2 适用: 人, 大鼠 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1F10 unconjugated
anti-Homeodomain Interacting Protein Kinase 2 (HIPK2) (AA 384-433) antibodyHIPK2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼, Bat, Hamster, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Homeodomain Interacting Protein Kinase 2 (HIPK2) antibodyHIPK2 适用: 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- HIPK2 (Homeodomain Interacting Protein Kinase 2 (HIPK2))
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别名
- HIPK2
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背景
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Description: Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis.
Gene: HIPK2
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分子量
- 131 kDa
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基因ID
- 28996
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UniProt
- Q9H2X6
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途径
- Cell Division Cycle
抗原
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