HIPK1/2/3 抗体
Quick Overview for HIPK1/2/3 抗体 (ABIN6272807)
抗原
适用
宿主
克隆类型
标记
应用范围
-
-
特异性
- HIPK1/2/3 Antibody detects endogenous levels of HIPK1/2/3
-
交叉反应
- 人, 小鼠, 大鼠
-
纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
-
免疫原
- A synthesized peptide derived from human HIPK1/2/3
-
亚型
- IgG
-
-
anti-HIPK1/2/3 antibody
适用: 人, 小鼠, 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB 1:500-1:2000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
-
有效期
- 12 months
-
-
- HIPK1/2/3
-
背景
-
Description: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.
Gene: HIPK1
-
分子量
- 130kDa
-
基因ID
- 204851
-
UniProt
- Q86Z02, Q9H2X6, Q9H422
抗原
-
