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HEY1 抗体 (Internal Region)

This anti-HEY1 antibody is a 兔 多克隆 antibody detecting HEY1 in WB, IHC, IF 和 ICC. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN6262226
发货至: 中国

Quick Overview for HEY1 抗体 (Internal Region) (ABIN6262226)

抗原

See all HEY1 抗体
HEY1 (Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

  • 22
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多克隆

标记

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This HEY1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
  • 抗原表位

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    Internal Region

    特异性

    HEY1 Antibody detects endogenous levels of total HEY1.

    预测反应

    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

    纯化方法

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    免疫原

    A synthesized peptide derived from human HEY1, corresponding to a region within the internal amino acids.

    亚型

    IgG
  • 应用备注

    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20 °C. Stable for 12 months from date of receipt.

    有效期

    12 months
  • 抗原

    HEY1 (Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1))

    别名

    HEY1

    背景

    Description: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737).

    Gene: HEY1

    分子量

    32-34 kDa

    基因ID

    23462

    UniProt

    Q9Y5J3

    途径

    Tube Formation
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