HCK 抗体 (C-Term)
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北京 101111
Quick Overview for HCK 抗体 (C-Term) (ABIN6262165)
抗原
See all HCK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- Hck Antibody detects endogenous levels of total Hck.
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预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human Hck, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Hemopoietic Cell Kinase (HCK) (AA 2-526) antibody
HCK 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hemopoietic Cell Kinase (HCK) (AA 1-505) antibodyHCK 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-Hemopoietic Cell Kinase (HCK) (AA 1-505) antibodyHCK 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Hemopoietic Cell Kinase (HCK) (AA 1-80) antibodyHCK 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 2A6 unconjugated
anti-Hemopoietic Cell Kinase (HCK) antibodyHCK 适用: 人 WB, IF, IF (cc) 宿主: 小鼠 Monoclonal 8C1 unconjugated
anti-Hemopoietic Cell Kinase (HCK) (AA 1-505) antibodyHCK 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1D9-1A9 unconjugated
anti-Hemopoietic Cell Kinase (HCK) antibodyHCK 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 3D12E10 unconjugated
anti-Hemopoietic Cell Kinase (HCK) (AA 131-156), (N-Term) antibodyHCK 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB20667 unconjugated
anti-Hemopoietic Cell Kinase (HCK) (AA 1-220) antibodyHCK 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hemopoietic Cell Kinase (HCK) (AA 1-220) antibodyHCK 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- HCK (Hemopoietic Cell Kinase (HCK))
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别名
- HCK
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背景
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Description: Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS.
Gene: HCK
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分子量
- 57kDa
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基因ID
- 3055
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UniProt
- P08631
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途径
- Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
抗原
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