HCFC1 抗体 (N-Term)
Quick Overview for HCFC1 抗体 (N-Term) (ABIN6262160)
抗原
See all HCFC1 抗体适用
宿主
克隆类型
标记
应用范围
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                                            抗原表位
- N-Term
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                                            特异性
- HCFC1 Antibody detects endogenous levels of total HCFC1.
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                                            预测反应
- Pig,Bovine,Horse,Rabbit,Dog,Xenopus
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                                            纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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                                            免疫原
- A synthesized peptide derived from human HCFC1, corresponding to a region within N-terminal amino acids.
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                                            亚型
- IgG
 
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                                            应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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                                            限制
- 仅限研究用
 
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                                            状态
- Liquid
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                                            浓度
- 1 mg/mL
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                                            缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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                                            储存液
- Sodium azide
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                                            注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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                                            储存条件
- -20 °C
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                                            储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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                                            有效期
- 12 months
 
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    - HCFC1 (Host Cell Factor C1 (VP16-Accessory Protein) (HCFC1))
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                                            别名
- HCFC1
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                                            背景
- 
                        Description: Involved in control of the cell cycle (PubMed:10629049, PubMed:10779346, PubMed:15190068, PubMed:16624878, PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2, represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337, PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100, PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655). Gene: HCFC1 
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                                            分子量
- 209kDa
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                                            基因ID
- 3054
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                                            UniProt
- P51610
 抗原
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