GRIA4 抗体
Quick Overview for GRIA4 抗体 (ABIN6262083)
抗原
See all GRIA4 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- GRIA4 Antibody detects endogenous levels of total GRIA4
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human GRIA4
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亚型
- IgG
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应用备注
- WB 1:1000-3000, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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- GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4))
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别名
- GRIA4
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背景
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Description: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Gene: GRIA4
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分子量
- 120 kDa
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基因ID
- 2893
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UniProt
- P48058
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途径
- PI3K-Akt Signaling
抗原
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