GABBR1 抗体 (C-Term)
Quick Overview for GABBR1 抗体 (C-Term) (ABIN6261856)
抗原
See all GABBR1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
特异性
- GABBR1 Antibody detects endogenous levels of total GABBR1.
-
预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
-
纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
-
免疫原
- A synthesized peptide derived from human GABBR1, corresponding to a region within C-terminal amino acids.
-
亚型
- IgG
-
-
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 52-151) antibody
GABBR1 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 2D7 unconjugated
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) antibodyGABBR1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibodyGABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 unconjugated
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (HRP)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 HRP
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (FITC)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 FITC
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (Biotin)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 Biotin
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (PE)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 PE
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (PerCP)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 PerCP
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (APC)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 APC
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (Atto 488)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 Atto 488
-
-
应用备注
- WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
-
有效期
- 12 months
-
-
- GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))
-
别名
- GABBR1
-
背景
-
Description: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10906333, PubMed:10773016, PubMed:10075644, PubMed:9872744, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9844003, PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen (PubMed:9844003, PubMed:9872316, PubMed:24305054).
Gene: GABBR1
-
分子量
- 110kDa
-
基因ID
- 2550
-
UniProt
- Q9UBS5
-
途径
- Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process
抗原
-
