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Fibrillin 1 抗体 (C-Term)

Name: Fibrillin 1 抗体 (C-Term)
SKU: ABIN6261744
Availability: OutOfStock

This 兔多克隆 anti-Fibrillin 1 antibody specifically detects Fibrillin 1 in WB, IHC, ELISA, ICC 和 IF. The antibody is reactive with 人, 小鼠和大鼠 samples.

ABIN6266778 at 1/100 staining human ovarian cancer tissue sections by IHC-P. (Fibrillin 1 抗体 (C-Term))

IHC

1 image

产品编号 ABIN6261744

发货至: 中国

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Quick Overview for Fibrillin 1 抗体 (C-Term) (ABIN6261744)

抗原

See all Fibrillin 1 (FBN1) 抗体

Fibrillin 1 (FBN1)

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This Fibrillin 1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Discover our top product FBN1 Primary Antibody

抗原表位
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C-Term

特异性

Fibrillin 1 Antibody detects endogenous levels of total Fibrillin 1.

预测反应

Pig,Bovine,Horse,Sheep,Rabbit

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human Fibrillin 1, corresponding to a region within C-terminal amino acids.

亚型

IgG
anti-Fibrillin 1 (FBN1) (AA 246-389) antibody
FBN1 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Fibrillin 1 (FBN1) (AA 751-895) antibody
FBN1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Fibrillin 1 (FBN1) (Internal Region) antibody
Verified FBN1 适用: 人 ELISA, IF 宿主: 山羊 Polyclonal unconjugated

anti-Fibrillin 1 (FBN1) (AA 723-902) antibody
FBN1 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Fibrillin 1 (FBN1) (AA 1703-1889) antibody
FBN1 适用: 小鼠 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Fibrillin 1 (FBN1) (AA 959-1145) antibody
FBN1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Fibrillin 1 (FBN1) (AA 168-364) antibody
FBN1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Fibrillin 1 (FBN1) (AA 401-500) antibody
FBN1 适用: 人, 大鼠 ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

anti-Fibrillin 1 (FBN1) (AA 2772-2871) antibody
FBN1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3H6 unconjugated

anti-Fibrillin 1 (FBN1) (AA 723-902) antibody
FBN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

IHC 1:50-1:200, WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

Fibrillin 1 (FBN1)

别名

FBN1

背景

Description: Fibrillin-1: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:1860873, PubMed:15062093). Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca2+ signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887, PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921).
Gene: FBN1

分子量

312kDa

基因ID

2200

UniProt

P35555

途径

Maintenance of Protein Location, SARS-CoV-2 Protein Interactome