Fibrillin 1 抗体 (C-Term)
Quick Overview for Fibrillin 1 抗体 (C-Term) (ABIN6261744)
抗原
See all Fibrillin 1 (FBN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- Fibrillin 1 Antibody detects endogenous levels of total Fibrillin 1.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human Fibrillin 1, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Fibrillin 1 (FBN1) (AA 246-389) antibody
FBN1 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fibrillin 1 (FBN1) (AA 751-895) antibodyFBN1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibrillin 1 (FBN1) (Internal Region) antibodyVerified FBN1 适用: 人 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Fibrillin 1 (FBN1) (AA 723-902) antibodyFBN1 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fibrillin 1 (FBN1) (AA 1703-1889) antibodyFBN1 适用: 小鼠 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fibrillin 1 (FBN1) (AA 360-460) antibodyFBN1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Fibrillin 1 (FBN1) (AA 959-1145) antibodyFBN1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibrillin 1 (FBN1) (AA 168-364) antibodyFBN1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibrillin 1 (FBN1) (AA 401-500) antibodyFBN1 适用: 人, 大鼠 ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Fibrillin 1 (FBN1) (AA 2772-2871) antibodyFBN1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3H6 unconjugated
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应用备注
- IHC 1:50-1:200, WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- Fibrillin 1 (FBN1)
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别名
- FBN1
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背景
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Description: Fibrillin-1: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:1860873, PubMed:15062093). Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11. This leads to disruption of TNFSF11-induced Ca2+ signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887, PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921).
Gene: FBN1
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分子量
- 312kDa
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基因ID
- 2200
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UniProt
- P35555
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途径
- Maintenance of Protein Location, SARS-CoV-2 Protein Interactome
抗原
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