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EHMT2 抗体 (N-Term)

This anti-EHMT2 antibody is a 兔 多克隆 antibody detecting EHMT2 in WB, IHC 和 ELISA. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN6261470
发货至: 中国
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中国
北京 101111
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Quick Overview for EHMT2 抗体 (N-Term) (ABIN6261470)

抗原

See all EHMT2 抗体
EHMT2 (Ankyrin Repeat-Containing Protein (EHMT2))

适用

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人, 小鼠, 大鼠

宿主

  • 66
  • 2
  • 1

克隆类型

  • 41
  • 28
多克隆

标记

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This EHMT2 antibody is un-conjugated

应用范围

  • 58
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Western Blotting (WB), Immunohistochemistry (IHC), ELISA
  • 抗原表位

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    N-Term

    特异性

    EHMT2 Antibody detects endogenous levels of total EHMT2.

    纯化方法

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    免疫原

    A synthesized peptide derived from human EHMT2, corresponding to a region within N-terminal amino acids.

    亚型

    IgG
  • 应用备注

    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20 °C. Stable for 12 months from date of receipt.

    有效期

    12 months
  • 抗原

    EHMT2 (Ankyrin Repeat-Containing Protein (EHMT2))

    别名

    EHMT2

    背景

    Description: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.

    Gene: EHMT2

    分子量

    132kDa

    基因ID

    10919

    UniProt

    Q96KQ7
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