UBR5 抗体 (N-Term)
Quick Overview for UBR5 抗体 (N-Term) (ABIN6261428)
抗原
See all UBR5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- EDD Antibody detects endogenous levels of total EDD.
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预测反应
- Zebrafish,Horse,Sheep,Rabbit,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human EDD, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) antibody
UBR5 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) (C-Term) antibodyVerified UBR5 适用: 人 IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) antibodyUBR5 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) (AA 600-650) antibodyUBR5 适用: 人, 小鼠 WB, IHC, IHC (p), IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) (N-Term) antibodyUBR5 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) (N-Term) antibodyUBR5 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) (AA 550-760) antibodyUBR5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) (N-Term) antibodyUBR5 适用: 人, 小鼠, Cow, 犬, Pig, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) (AA 1-50) antibodyUBR5 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5))
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别名
- UBR5
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背景
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Description: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
Gene: UBR5
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分子量
- 309kDa
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基因ID
- 51366
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UniProt
- O95071
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
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