CREB3L1 抗体 (N-Term)
Quick Overview for CREB3L1 抗体 (N-Term) (ABIN6261026)
抗原
See all CREB3L1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- CREB3L1,OASIS Antibody detects endogenous levels of total CREB3L1,OASIS.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CREB3L1,OASIS, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (AA 396-500) antibody
CREB3L1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (C-Term) antibodyVerified CREB3L1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (AA 481-509), (C-Term) antibodyCREB3L1 适用: 人, 小鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB19585 unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (AA 1-519) antibodyCREB3L1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (C-Term) antibodyCREB3L1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) antibodyCREB3L1 适用: 人, 小鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (AA 488-517), (C-Term) antibodyCREB3L1 适用: 人, 小鼠 WB, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (AA 1-294) antibodyCREB3L1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (AA 1-519) antibodyCREB3L1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1) (N-Term) antibodyCREB3L1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, Pig, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- CREB3L1 (CAMP Responsive Element Binding Protein 3-Like 1 (CREB3L1))
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别名
- CREB3L1
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背景
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Description: Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (PubMed:25310401).
Gene: CREB3L1
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分子量
- 55-58 kDa and 84 kDa
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基因ID
- 90993
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UniProt
- Q96BA8
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途径
- Thyroid Hormone Synthesis, Chromatin Binding
抗原
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