COMMD1 抗体 (Internal Region)
Quick Overview for COMMD1 抗体 (Internal Region) (ABIN6260960)
抗原
See all COMMD1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Internal Region
-
特异性
- COMMD1 Antibody detects endogenous levels of total COMMD1.
-
预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog
-
纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
-
免疫原
- A synthesized peptide derived from human COMMD1, corresponding to a region within the internal amino acids.
-
亚型
- IgG
-
-
anti-Copper Metabolism (Murr1) Domain Containing 1 (COMMD1) (AA 1-190) antibody
COMMD1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2A12 unconjugated
anti-Copper Metabolism (Murr1) Domain Containing 1 (COMMD1) antibodyCOMMD1 适用: 人, 猴 WB, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 3B3 unconjugated
anti-Copper Metabolism (Murr1) Domain Containing 1 (COMMD1) antibodyCOMMD1 适用: 人 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 1G7 unconjugated
anti-Copper Metabolism (Murr1) Domain Containing 1 (COMMD1) (AA 1-190) antibodyCOMMD1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Copper Metabolism (Murr1) Domain Containing 1 (COMMD1) (AA 1-190) antibodyCOMMD1 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 2B12 unconjugated
anti-Copper Metabolism (Murr1) Domain Containing 1 (COMMD1) (AA 2-190) antibodyCOMMD1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Copper Metabolism (Murr1) Domain Containing 1 (COMMD1) (AA 1-190) antibodyCOMMD1 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Copper Metabolism (Murr1) Domain Containing 1 (COMMD1) antibodyCOMMD1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Copper Metabolism (Murr1) Domain Containing 1 (COMMD1) (AA 1-190) antibodyCOMMD1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Copper Metabolism (Murr1) Domain Containing 1 (COMMD1) antibodyCOMMD1 适用: 人 WB 宿主: 兔 Polyclonal RB54338 unconjugated
-
-
应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
-
有效期
- 12 months
-
-
- COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))
-
别名
- COMMD1
-
背景
-
Description: Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1, in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 (PubMed:21778237). Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity (PubMed:15799966, PubMed:17183367, PubMed:20048074). Involved in the regulation of membrane expression and ubiquitination of SLC12A2 (PubMed:23515529). Modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes (PubMed:14645214, PubMed:20237237, PubMed:21741370). Promotes CFTR cell surface expression through regulation of its ubiquitination (PubMed:21483833). Down-regulates SOD1 activity by interfering with its homodimerization (PubMed:20595380). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery, the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). Can bind one copper ion per monomer (PubMed:17309234). May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:18940794). Involved in the regulation of HIF1A-mediated transcription, competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 (PubMed:20458141).
Gene: COMMD1
-
分子量
- 21 kDa
-
基因ID
- 150684
-
UniProt
- Q8N668
-
途径
- Transition Metal Ion Homeostasis
抗原
-
