CHD8 抗体 (C-Term)
Quick Overview for CHD8 抗体 (C-Term) (ABIN6260798)
抗原
See all CHD8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- CHD8 Antibody detects endogenous levels of total CHD8.
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预测反应
- Bovine,Horse,Sheep,Dog,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CHD8, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Chromodomain Helicase DNA Binding Protein 8 (CHD8) (AA 1980-2078) antibody
CHD8 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Chromodomain Helicase DNA Binding Protein 8 (CHD8) (AA 1980-2078) antibodyCHD8 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C8 unconjugated
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应用备注
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- CHD8 (Chromodomain Helicase DNA Binding Protein 8 (CHD8))
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别名
- CHD8
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背景
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Description: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
Gene: CHD8
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分子量
- 290kDa
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基因ID
- 57680
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UniProt
- Q9HCK8
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途径
- Chromatin Binding
抗原
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