CDYL 抗体 (C-Term)
Quick Overview for CDYL 抗体 (C-Term) (ABIN6260735)
抗原
See all CDYL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- CDYL1 Antibody detects endogenous levels of total CDYL1.
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预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CDYL1, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Chromodomain Protein, Y-Like (CDYL) (AA 153-260) antibody
CDYL 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1A6 unconjugated
anti-Chromodomain Protein, Y-Like (CDYL) (AA 1-544) antibodyCDYL 适用: 人 WB, IHC, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chromodomain Protein, Y-Like (CDYL) (N-Term) antibodyCDYL 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 马, 豚鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromodomain Protein, Y-Like (CDYL) (AA 8-260) antibodyCDYL 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chromodomain Protein, Y-Like (CDYL) (C-Term) antibodyVerified CDYL 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Chromodomain Protein, Y-Like (CDYL) (C-Term) antibodyCDYL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chromodomain Protein, Y-Like (CDYL) (AA 51-100) antibodyCDYL 适用: 人, 小鼠, 大鼠, 犬, 马, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Chromodomain Protein, Y-Like (CDYL) (AA 245-544) antibodyCDYL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- CDYL (Chromodomain Protein, Y-Like (CDYL))
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别名
- CDYL
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背景
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Description: Isoform 2: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:28402439). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2), acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (PubMed:22009739). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (PubMed:19061646). Involved X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). In addition to act as a chromatin reader, acts as a hydro-lyase (PubMed:28803779). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (PubMed:28803779). Histone crotonylation is required during spermatogenesis, down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity).
Gene: CDYL
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分子量
- 66 kDa
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基因ID
- 9425
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UniProt
- Q9Y232
抗原
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