CCDC22 抗体 (C-Term)
Quick Overview for CCDC22 抗体 (C-Term) (ABIN6260528)
抗原
See all CCDC22 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- CCDC22 Antibody detects endogenous levels of total CCDC22.
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预测反应
- Pig,Horse,Sheep,Rabbit,Dog,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CCDC22, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Coiled-Coil Domain Containing 22 (CCDC22) (N-Term) antibody
CCDC22 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Coiled-Coil Domain Containing 22 (CCDC22) (AA 530-558), (C-Term) antibodyCCDC22 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB33346 unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- CCDC22 (Coiled-Coil Domain Containing 22 (CCDC22))
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别名
- CCDC22
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背景
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Description: Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation, the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery, the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947).
Gene: CCDC22
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分子量
- 71 kDa
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基因ID
- 28952
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UniProt
- O60826
抗原
-
