CARD9 抗体 (C-Term)
Quick Overview for CARD9 抗体 (C-Term) (ABIN6260462)
抗原
See all CARD9 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- CARD9 Antibody detects endogenous levels of total CARD9.
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预测反应
- Pig,Zebrafish,Bovine,Horse,Dog,Chicken
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CARD9, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Caspase Recruitment Domain Family, Member 9 (CARD9) (AA 26-283) antibody
CARD9 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase Recruitment Domain Family, Member 9 (CARD9) (AA 274-530) antibodyCARD9 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Caspase Recruitment Domain Family, Member 9 (CARD9) (AA 237-536) antibodyCARD9 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Caspase Recruitment Domain Family, Member 9 (CARD9) (AA 521-536) antibodyCARD9 适用: 人, 猴 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Caspase Recruitment Domain Family, Member 9 (CARD9) (AA 1-492) antibodyCARD9 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Caspase Recruitment Domain Family, Member 9 (CARD9) (AA 467-516) antibodyCARD9 适用: 人, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Caspase Recruitment Domain Family, Member 9 (CARD9) (Middle Region) antibodyCARD9 适用: 人, 小鼠, 马, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Caspase Recruitment Domain Family, Member 9 (CARD9) antibodyCARD9 适用: 人 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, IF/ICC 1:200-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))
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别名
- CARD9
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背景
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Description: Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells.
Gene: CARD9
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分子量
- 62 kDa
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基因ID
- 64170
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UniProt
- Q9H257
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途径
- Activation of Innate immune Response
抗原
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