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- 抗原 See all AP2S1 抗体
- AP2S1 (Adaptor-Related Protein Complex 2, sigma 1 Subunit (AP2S1))
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This AP2S1 antibody is un-conjugated
- 应用范围
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- AP2S1 Antibody detects endogenous levels of total AP2S1.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human AP2S1, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product AP2S1 Primary Antibody
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anti-Adaptor-Related Protein Complex 2, sigma 1 Subunit (AP2S1) (AA 1-142) antibody
AP2S1 适用: 人 ELISA, WB, RNAi 宿主: 小鼠 Monoclonal 3E4 unconjugated
anti-Adaptor-Related Protein Complex 2, sigma 1 Subunit (AP2S1) (AA 1-142) antibodyAP2S1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, sigma 1 Subunit (AP2S1) antibodyAP2S1 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, sigma 1 Subunit (AP2S1) (AA 1-142) antibodyAP2S1 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, sigma 1 Subunit (AP2S1) (AA 1-142) antibodyAP2S1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, sigma 1 Subunit (AP2S1) antibodyAP2S1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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- 应用备注
- WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- AP2S1 (Adaptor-Related Protein Complex 2, sigma 1 Subunit (AP2S1))
- 别名
- AP2S1 (AP2S1 产品)
- 别名
- AP2S1 antibody, ap17 antibody, claps2 antibody, ap17-delta antibody, DDBDRAFT_0188542 antibody, DDBDRAFT_0234236 antibody, DDB_0188542 antibody, DDB_0234236 antibody, MGC85224 antibody, AP17 antibody, AP17-DELTA antibody, CLAPS2 antibody, HHC3 antibody, AI043088 antibody, Ap17 antibody, adaptor related protein complex 2 sigma 1 subunit antibody, adaptor-related protein complex 2, sigma 1 subunit antibody, adaptor related protein complex 2 sigma 1 subunit S homeolog antibody, AP2S1 antibody, ap2s1 antibody, ap2s1.S antibody, Ap2s1 antibody
- 背景
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Description: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). May also play a role in extracellular calcium homeostasis.
Gene: AP2S1
- 分子量
- 17 kDa
- 基因ID
- 1175
- UniProt
- P53680
- 途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation
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