AKAP8 抗体 (Internal Region)
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北京 101111
Quick Overview for AKAP8 抗体 (Internal Region) (ABIN6259857)
抗原
See all AKAP8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- AKAP8 Antibody detects endogenous levels of total AKAP8.
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预测反应
- Bovine,Horse,Sheep,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human AKAP8, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) antibody
KD Validated AKAP8 适用: 人 WB, IF (p) 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (AA 551-662) antibodyAKAP8 适用: 人 WB, IF, ELISA, IHC (p), IP 宿主: 小鼠 Monoclonal 3D4 unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (AA 1-692) antibodyAKAP8 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (Internal Region) antibodyAKAP8 适用: 人 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (AA 480-692) antibodyAKAP8 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (Internal Region) antibodyAKAP8 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (AA 1-692) antibodyAKAP8 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (AA 331-380) antibodyAKAP8 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (AA 395-430) antibodyAKAP8 适用: 人 WB 宿主: 兔 Polyclonal RB52720 unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (N-Term) antibodyVerified AKAP8 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC: 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- AKAP8 (A Kinase (PRKA) Anchor Protein 8 (AKAP8))
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别名
- AKAP8
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背景
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Description: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation, the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3, in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). Seems to involved in modulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro and associates to GC-rich ribosomal RNA promoters (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation, the function probably implicates targeting of PKA to NFKB1 (By similarity).
Gene: AKAP8
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分子量
- 76kDa
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基因ID
- 10270
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UniProt
- O43823
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途径
- SARS-CoV-2 Protein Interactome
抗原
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