AHCYL1 抗体 (N-Term)
Quick Overview for AHCYL1 抗体 (N-Term) (ABIN6259835)
抗原
See all AHCYL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- AHCYL1 Antibody detects endogenous levels of total AHCYL1.
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human AHCYL1, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-Adenosylhomocysteinase-Like 1 (AHCYL1) (AA 1-101) antibody
AHCYL1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5D6 unconjugated
anti-Adenosylhomocysteinase-Like 1 (AHCYL1) (AA 31-260) antibodyAHCYL1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adenosylhomocysteinase-Like 1 (AHCYL1) antibodyAHCYL1 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenosylhomocysteinase-Like 1 (AHCYL1) (AA 1-101) antibodyAHCYL1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Adenosylhomocysteinase-Like 1 (AHCYL1) (N-Term) antibodyAHCYL1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, 犬, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Adenosylhomocysteinase-Like 1 (AHCYL1) (N-Term) antibodyAHCYL1 适用: 人, 小鼠, 大鼠, Cow, 犬, 斑马鱼, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Adenosylhomocysteinase-Like 1 (AHCYL1) antibodyAHCYL1 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adenosylhomocysteinase-Like 1 (AHCYL1) (AA 1-530) antibodyAHCYL1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Adenosylhomocysteinase-Like 1 (AHCYL1) (C-Term) antibodyAHCYL1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Adenosylhomocysteinase-Like 1 (AHCYL1) (N-Term) antibodyAHCYL1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- AHCYL1 (Adenosylhomocysteinase-Like 1 (AHCYL1))
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别名
- AHCYL1
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背景
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Description: Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3- and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3- secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity).
Gene: AHCYL1
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分子量
- 60 kDa
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基因ID
- 10768
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UniProt
- O43865
抗原
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