TADA2L 抗体
Quick Overview for TADA2L 抗体 (ABIN6259764)
抗原
See all TADA2L (TADA2A) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- ADA2L antibody detects endogenous levels of total ADA2L
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交叉反应
- 人, 猴, 小鼠, 大鼠
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human ADA2L
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亚型
- IgG
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应用备注
- WB: 1:500~1:3000, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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- TADA2L (TADA2A) (Transcriptional Adaptor 2A (TADA2A))
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别名
- ADA2L
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背景
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Description: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376).
Gene: TADA2A
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分子量
- 47kDa
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基因ID
- 6871
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UniProt
- O75478
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途径
- Chromatin Binding
抗原
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