ACIN1 抗体
Quick Overview for ACIN1 抗体 (ABIN6259729)
抗原
See all ACIN1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- ACINU Antibody detects endogenous levels of total ACINU
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human ACINU
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亚型
- IgG
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anti-Apoptotic Chromatin Condensation Inducer 1 (ACIN1) antibody
ACIN1 适用: 人 WB, ICC, DB 宿主: 小鼠 Monoclonal 2005C3a unconjugated
anti-Apoptotic Chromatin Condensation Inducer 1 (ACIN1) (C-Term) antibodyACIN1 适用: 人 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Apoptotic Chromatin Condensation Inducer 1 (ACIN1) (AA 994-1009) antibodyACIN1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Apoptotic Chromatin Condensation Inducer 1 (ACIN1) (Cytoplasmic Domain) antibodyACIN1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Apoptotic Chromatin Condensation Inducer 1 (ACIN1) (AA 1-523), (N-Term) antibodyACIN1 适用: 人 WB, IP 宿主: 小鼠 Monoclonal 3H8 unconjugated
anti-Apoptotic Chromatin Condensation Inducer 1 (ACIN1) (Intermediate Domain) antibodyACIN1 适用: 人 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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- ACIN1 (Apoptotic Chromatin Condensation Inducer 1 (ACIN1))
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别名
- ACINU
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背景
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Description: Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets, ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.
Gene: ACIN1
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分子量
- 152 kDa
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基因ID
- 22985
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UniProt
- Q9UKV3
抗原
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