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- 抗原 See all ASIC1 (ACCN2) 抗体
- ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ASIC1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- 特异性
- ACCN2 Antibody detects endogenous levels of total ACCN2.
- 预测反应
- Pig,Bovine,Sheep,Rabbit,Dog,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human ACCN2, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product ACCN2 Primary Antibody
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anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (N-Term) antibody
ACCN2 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (C-Term) antibodyVerified ACCN2 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (AA 460-526) antibodyACCN2 适用: 小鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S271-44 unconjugated
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (AA 460-526) antibody (HRP)ACCN2 适用: 小鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S271-44 HRP
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (AA 460-526) antibody (FITC)ACCN2 适用: 小鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S271-44 FITC
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (AA 460-526) antibody (Alkaline Phosphatase (AP))ACCN2 适用: 小鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S271-44 Alkaline Phosphatase (AP)
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (AA 460-526) antibody (Biotin)ACCN2 适用: 小鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S271-44 Biotin
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (AA 460-526) antibody (PE)ACCN2 适用: 小鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S271-44 PE
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (AA 460-526) antibody (APC)ACCN2 适用: 小鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S271-44 APC
anti-Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) (AA 460-526) antibody (PerCP)ACCN2 适用: 小鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S271-44 PerCP
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- 应用备注
- WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))
- 别名
- ASIC1 (ACCN2 产品)
- 别名
- ACCN2 antibody, ASIC antibody, BNaC2 antibody, Accn2 antibody, ASIC1 antibody, AI843610 antibody, ASIC1a antibody, B530003N02Rik antibody, acid sensing ion channel subunit 1 antibody, acid-sensing (proton-gated) ion channel 1 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 antibody, ASIC1 antibody, Asic1 antibody, asic1 antibody, SMARCD1 antibody
- 背景
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Description: Isoform 2 and isoform 3 function as proton-gated sodium channels, they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
Gene: ASIC1
- 分子量
- 60 kDa
- 基因ID
- 41
- UniProt
- P78348
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