YOD1 抗体 (Internal Region)
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北京 101111
Quick Overview for YOD1 抗体 (Internal Region) (ABIN6259576)
抗原
See all YOD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- YOD1 Antibody detects endogenous levels of total YOD1.
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human YOD1, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Ubiquitin Thioesterase OTU1 (YOD1) (AA 319-347), (C-Term) antibody
YOD1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB29107 unconjugated
anti-Ubiquitin Thioesterase OTU1 (YOD1) (AA 1-348) antibodyYOD1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Thioesterase OTU1 (YOD1) (AA 1-44) antibodyYOD1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Thioesterase OTU1 (YOD1) antibodyYOD1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Thioesterase OTU1 (YOD1) (AA 326-355), (C-Term) antibodyYOD1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- YOD1 (Ubiquitin Thioesterase OTU1 (YOD1))
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别名
- YOD1
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背景
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Description: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation (PubMed:27753622).
Gene: YOD1
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分子量
- 35 kDa
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基因ID
- 55432
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UniProt
- Q5VVQ6
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途径
- ER-Nucleus Signaling
抗原
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