FIL1h 抗体 (C-Term)
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北京 101111
Quick Overview for FIL1h 抗体 (C-Term) (ABIN6259273)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- IL1F8 Antibody detects endogenous levels of total IL1F8.
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human IL1F8, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Interleukin 1 eta (FIL1h) (AA 1-157) antibody
FIL1h 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E4 unconjugated
anti-Interleukin 1 eta (FIL1h) (AA 1-157) antibodyFIL1h 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Interleukin 1 eta (FIL1h) (AA 1-30), (N-Term) antibodyFIL1h 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB22631 unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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有效期
- 12 months
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- FIL1h (Interleukin 1 eta (FIL1h))
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别名
- IL36B
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背景
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Description: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response, similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.
Gene: IL36B
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分子量
- 17 kDa?
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基因ID
- 27177
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UniProt
- Q9NZH7
抗原
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