APITD1 抗体 (C-Term)
Quick Overview for APITD1 抗体 (C-Term) (ABIN6259030)
抗原
See all APITD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- CENPS Antibody detects endogenous levels of total CENPS.
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CENPS, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1) (AA 1-138) antibody
APITD1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1) (AA 48-74) antibodyAPITD1 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23840 unconjugated
anti-Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1) (AA 1-138) antibodyAPITD1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6F16 unconjugated
anti-Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1) (AA 1-138) antibodyAPITD1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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有效期
- 12 months
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- APITD1 (Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1))
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别名
- CENPS
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背景
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Description: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM (PubMed:20347428, PubMed:20347429). In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428). In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:22304917). DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347428, PubMed:20347429).
Gene: CENPS
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分子量
- 16 kDa
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基因ID
- 100526739, 378708
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UniProt
- Q8N2Z9
抗原
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