IREM1 抗体 (Internal Region)
Quick Overview for IREM1 抗体 (Internal Region) (ABIN6258909)
抗原
See all IREM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- CLM-1 Antibody detects endogenous levels of total CLM-1.
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CLM-1, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Immune Receptor Expressed On Myeloid Cells 1 (IREM1) (AA 45-310) antibody
IREM1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Immune Receptor Expressed On Myeloid Cells 1 (IREM1) (Internal Region) antibodyIREM1 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Immune Receptor Expressed On Myeloid Cells 1 (IREM1) (AA 56-84), (N-Term) antibodyIREM1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22264 unconjugated
anti-Immune Receptor Expressed On Myeloid Cells 1 (IREM1) (AA 63-92), (N-Term) antibodyIREM1 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Immune Receptor Expressed On Myeloid Cells 1 (IREM1) (AA 23-150) antibodyIREM1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Immune Receptor Expressed On Myeloid Cells 1 (IREM1) (Internal Region) antibodyIREM1 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- IREM1 (Immune Receptor Expressed On Myeloid Cells 1 (IREM1))
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别名
- CD300LF
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背景
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Description: Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition, recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity).
Gene: CD300LF
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分子量
- 30 kDa
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基因ID
- 146722
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UniProt
- Q8TDQ1
抗原
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