IREM1 抗体 (Internal Region)
Our Local Distributor
北京 101111
Quick Overview for IREM1 抗体 (Internal Region) (ABIN6258909)
抗原
See all IREM1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Internal Region
-
特异性
- CLM-1 Antibody detects endogenous levels of total CLM-1.
-
纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
-
免疫原
- A synthesized peptide derived from human CLM-1, corresponding to a region within the internal amino acids.
-
亚型
- IgG
-
-
anti-Immune Receptor Expressed On Myeloid Cells 1 (IREM1) (AA 45-310) antibody
IREM1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Immune Receptor Expressed On Myeloid Cells 1 (IREM1) (Internal Region) antibodyIREM1 适用: 人 ELISA, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Immune Receptor Expressed On Myeloid Cells 1 (IREM1) (AA 20-156) antibodyIREM1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Immune Receptor Expressed On Myeloid Cells 1 (IREM1) (AA 56-84), (N-Term) antibodyIREM1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22264 unconjugated
anti-Immune Receptor Expressed On Myeloid Cells 1 (IREM1) (AA 63-92), (N-Term) antibodyIREM1 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Immune Receptor Expressed On Myeloid Cells 1 (IREM1) (Internal Region) antibodyIREM1 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
-
有效期
- 12 months
-
-
- IREM1 (Immune Receptor Expressed On Myeloid Cells 1 (IREM1))
-
别名
- CD300LF
-
背景
-
Description: Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition, recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity).
Gene: CD300LF
-
分子量
- 30 kDa
-
基因ID
- 146722
-
UniProt
- Q8TDQ1
抗原
-
