MAP4K2 抗体 (Internal Region)
Quick Overview for MAP4K2 抗体 (Internal Region) (ABIN6258837)
抗原
See all MAP4K2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- MAP4K2 Antibody detects endogenous levels of total MAP4K2.
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预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human MAP4K2, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 386-469) antibody
MAP4K2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 1-820) antibodyMAP4K2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 36-85) antibodyMAP4K2 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 斑马鱼, 犬, Pig, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 216-265) antibodyMAP4K2 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 斑马鱼, 马, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 551-820) antibodyMAP4K2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (N-Term) antibodyMAP4K2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (N-Term) antibodyMAP4K2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 321-349) antibodyMAP4K2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB32275 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 288-319) antibodyMAP4K2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB1204 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 320-349), (Middle Region) antibodyMAP4K2 适用: 人 WB, FACS, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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有效期
- 12 months
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- MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))
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别名
- MAP4K2
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背景
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Description: Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.
Gene: MAP4K2
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分子量
- 91 kDa
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基因ID
- 5871
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UniProt
- Q12851
抗原
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