KAT2A 抗体 (C-Term)
Quick Overview for KAT2A 抗体 (C-Term) (ABIN6258818)
抗原
See all KAT2A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- GCN5L2 Antibody detects endogenous levels of total GCN5L2.
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预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human GCN5L2, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-K(lysine) Acetyltransferase 2A (KAT2A) antibody
KAT2A 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (AA 1-100) antibodyKAT2A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (AA 738-837) antibodyKAT2A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F9 unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (AA 738-837) antibodyKAT2A 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4D3 unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (AA 738-837) antibodyKAT2A 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (C-Term) antibodyKAT2A 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (C-Term) antibodyKAT2A 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (AA 411-837) antibodyKAT2A 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal AT3G13 unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (AA 807-837) antibodyKAT2A 适用: 人, 小鼠 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (AA 302-537) antibodyKAT2A 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- KAT2A (K(lysine) Acetyltransferase 2A (KAT2A))
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别名
- KAT2A
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背景
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Description: Protein lysine acyltransferase that can act both as a acetyltransferase and succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at Lys-9 (H3K9ac), leading to promote IL2 expression (By similarity). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:29174768, PubMed:27796307). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307).
Gene: KAT2A
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分子量
- 100 kDa
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基因ID
- 2648
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UniProt
- Q92830
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途径
- Chromatin Binding, Tube Formation
抗原
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