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AZI1 抗体 (C-Term)

AZI1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6258751
发货至: 中国
  • 抗原 See all AZI1 抗体
    AZI1 (5-Azacytidine Induced 1 (AZI1))
    抗原表位
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 17
    • 16
    • 10
    人, 小鼠
    宿主
    • 31
    克隆类型
    • 31
    多克隆
    标记
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AZI1 antibody is un-conjugated
    应用范围
    • 13
    • 13
    • 9
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    AZI1 Antibody detects endogenous levels of total AZI1.
    预测反应
    Zebrafish,Bovine,Horse,Sheep,Dog
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human AZI1, corresponding to a region within C-terminal amino acids.
    亚型
    IgG
  • 应用备注
    WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    AZI1 (5-Azacytidine Induced 1 (AZI1))
    别名
    CEP131 (AZI1 产品)
    别名
    AZ1 antibody, Cep131 antibody, ZA1 antibody, Azi antibody, centrosomal protein 131 antibody, CEP131 antibody, Cep131 antibody
    背景

    Description: Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Acts also as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation, may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression, may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).

    Gene: CEP131

    分子量
    130 kDa
    基因ID
    22994
    UniProt
    Q9UPN4
    途径
    M Phase
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