BRE 抗体 (C-Term)
Quick Overview for BRE 抗体 (C-Term) (ABIN6258458)
抗原
See all BRE 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- BRE Antibody detects endogenous levels of total BRE.
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预测反应
- Zebrafish,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human BRE, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (AA 51-229) antibody
BRE 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) antibodyKO Validated BRE 适用: 人 WB, IF, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (AA 94-383) antibodyBRE 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (AA 9-338) antibodyBRE 适用: 人, 小鼠 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (C-Term) antibodyBRE 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, Bat, 小鸡, Hamster, 猴, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (AA 1-415) antibodyBRE 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (N-Term) antibodyBRE 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
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别名
- BABAM2
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背景
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Description: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748). Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1, deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect (PubMed:15465831).
Gene: BABAM2
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分子量
- 47 kDa
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基因ID
- 9577
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UniProt
- Q9NXR7
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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