USP13 抗体 (C-Term)
Quick Overview for USP13 抗体 (C-Term) (ABIN6258346)
抗原
See all USP13 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- USP13 Antibody detects endogenous levels of total USP13.
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预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human USP13, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13) antibody
USP13 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13) (AA 500-550) antibodyUSP13 适用: 人, 小鼠, 犬, 马, Cow, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13) antibodyUSP13 适用: 人, 犬, 猴 WB, IHC, IP 宿主: 小鼠 Monoclonal 4G11 unconjugated
anti-Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13) (AA 387-420) antibodyUSP13 适用: 斑马鱼 WB 宿主: 兔 Polyclonal RB52034 unconjugated
anti-Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13) antibodyUSP13 适用: 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13) (AA 1-863) antibodyUSP13 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13) (AA 161-210) antibodyUSP13 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠, 兔, 猴, Pig, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13) (AA 90-200) antibodyUSP13 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13) (AA 389-419) antibodyUSP13 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB4304 unconjugated
anti-Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13) (AA 811-860) antibodyUSP13 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IHC: 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- USP13 (Ubiquitin Specific Peptidase 13 (Isopeptidase T-3) (USP13))
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别名
- USP13
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背景
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Description: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro, however, additional experiments are required to confirm such data.
Gene: USP13
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分子量
- 97 kDa
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基因ID
- 8975
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UniProt
- Q92995
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途径
- SARS-CoV-2 Protein Interactome
抗原
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