PIK3C2A 抗体 (C-Term)
Quick Overview for PIK3C2A 抗体 (C-Term) (ABIN6258303)
抗原
See all PIK3C2A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- PI 3 Kinase Class 2A Antibody detects endogenous levels of total PI 3 Kinase Class 2A.
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预测反应
- Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human PI 3 Kinase Class 2A, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide (PIK3C2A) (AA 172-403) antibody
PIK3C2A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide (PIK3C2A) (AA 1577-1686) antibodyPIK3C2A 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 3E7 unconjugated
anti-Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide (PIK3C2A) (C-Term) antibodyVerified PIK3C2A 适用: 人 IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide (PIK3C2A) (AA 1577-1687) antibodyPIK3C2A 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3E7 unconjugated
anti-Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide (PIK3C2A) (AA 349-611) antibodyPIK3C2A 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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有效期
- 12 months
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- PIK3C2A (Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide (PIK3C2A))
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别名
- PIK3C2A
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背景
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Description: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function.
Gene: PIK3C2A
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分子量
- 191 kDa
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基因ID
- 5286
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UniProt
- O00443
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途径
- EGFR Signaling Pathway, Inositol Metabolic Process, Platelet-derived growth Factor Receptor Signaling
抗原
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