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CKLF 抗体

CKLF 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6258091
发货至: 中国
  • 抗原 See all CKLF 抗体
    CKLF (Chemokine-Like Factor (CKLF))
    适用
    • 24
    • 18
    • 17
    人, 小鼠
    宿主
    • 25
    克隆类型
    • 25
    多克隆
    标记
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CKLF antibody is un-conjugated
    应用范围
    • 24
    • 13
    • 13
    • 11
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    CKLF6 Antibody detects endogenous levels of total CKLF6
    交叉反应
    人, 小鼠
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide
    亚型
    IgG
    Top Product
    Discover our top product CKLF Primary Antibody
  • 应用备注
    WB 1:500~1:1000, IF/ICC 1:100-1:500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C.Stable for 12 months from date of receipt
    有效期
    12 months
  • 抗原
    CKLF (Chemokine-Like Factor (CKLF))
    别名
    CKLF6 (CKLF 产品)
    别名
    C32 antibody, CKLF1 antibody, CKLF2 antibody, CKLF3 antibody, CKLF4 antibody, UCK-1 antibody, 1700001C14Rik antibody, 1810018M11Rik antibody, CKLF5 antibody, Cklf2 antibody, Cklf6 antibody, HSPC224 antibody, Cklf1 antibody, chemokine like factor antibody, chemokine-like factor antibody, CKLF antibody, Cklf antibody, LOC100727126 antibody, LOC101103916 antibody
    背景

    Description: Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.

    Gene: CMTM6

    分子量
    25 kDa
    基因ID
    54918
    UniProt
    Q9NX76
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