CBLN1 抗体 (C-Term)
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北京 101111
Quick Overview for CBLN1 抗体 (C-Term) (ABIN6258087)
抗原
See all CBLN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- CBLN1 Antibody detects endogenous levels of total CBLN1.
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预测反应
- Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CBLN1, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Cerebellin 1 Precursor (CBLN1) (C-Term) antibody
CBLN1 适用: 人, 大鼠, 小鼠, Cow, 猴, Pig, 犬, 豚鼠, 马, 兔, 斑马鱼, Bat, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Cerebellin 1 Precursor (CBLN1) (AA 22-193) antibodyCBLN1 适用: 人 WB, ICC, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Cerebellin 1 Precursor (CBLN1) (C-Term) antibodyCBLN1 适用: 人, 大鼠, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Cerebellin 1 Precursor (CBLN1) (C-Term) antibodyCBLN1 适用: 人, 大鼠, 小鼠, Cow, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Cerebellin 1 Precursor (CBLN1) (C-Term) antibodyCBLN1 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- CBLN1 (Cerebellin 1 Precursor (CBLN1))
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别名
- CBLN1
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背景
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Description: Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2. NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (PubMed:27418511).
Gene: CBLN1
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分子量
- 25 kDa
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基因ID
- 869
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UniProt
- P23435
抗原
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