CDC42BPA 抗体 (Internal Region)
Quick Overview for CDC42BPA 抗体 (Internal Region) (ABIN6258012)
抗原
See all CDC42BPA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- CDC42BPA Antibody detects endogenous levels of total CDC42BPA.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CDC42BPA, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-CDC42 Binding Protein Kinase alpha (DMPK-Like) (CDC42BPA) antibody
CDC42BPA 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CDC42 Binding Protein Kinase alpha (DMPK-Like) (CDC42BPA) (AA 551-650) antibodyCDC42BPA 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G7 unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- CDC42BPA (CDC42 Binding Protein Kinase alpha (DMPK-Like) (CDC42BPA))
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别名
- CDC42BPA
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背景
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Description: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity).
Gene: CDC42BPA
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分子量
- 97 kDa
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基因ID
- 8476
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UniProt
- Q5VT25
抗原
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