CD5L 抗体 (C-Term)
Quick Overview for CD5L 抗体 (C-Term) (ABIN6258003)
抗原
See all CD5L 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- CD5L Antibody detects endogenous levels of total CD5L.
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CD5L, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-CD5 Molecule-Like (CD5L) (AA 41-140) antibody
CD5L 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1C8 unconjugated
anti-CD5 Molecule-Like (CD5L) (AA 1-347) antibodyCD5L 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-CD5 Molecule-Like (CD5L) (AA 221-347) antibodyCD5L 适用: 小鼠, 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-CD5 Molecule-Like (CD5L) antibodyCD5L 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CD5 Molecule-Like (CD5L) (AA 64-93), (N-Term) antibodyCD5L 适用: 人 WB 宿主: 兔 Polyclonal RB41686 unconjugated
anti-CD5 Molecule-Like (CD5L) (C-Term) antibodyCD5L 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD5 Molecule-Like (CD5L) (N-Term) antibodyCD5L 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD5 Molecule-Like (CD5L) (AA 20-347) antibodyCD5L 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CD5 Molecule-Like (CD5L) (AA 133-256) antibodyCD5L 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD5 Molecule-Like (CD5L) antibodyCD5L 适用: 人 FACS 宿主: 兔 Chimeric unconjugated Fc fragment
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应用备注
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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有效期
- 12 months
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- CD5L (CD5 Molecule-Like (CD5L))
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别名
- CD5L
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背景
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Description: Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflammed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983).
Gene: CD5L
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分子量
- 38 kDa
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基因ID
- 922
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UniProt
- O43866
抗原
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