RED1 抗体 (Internal Region)
Quick Overview for RED1 抗体 (Internal Region) (ABIN6257927)
抗原
See all RED1 (ADARB1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- ADARB1 Antibody detects endogenous levels of total ADARB1.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human ADARB1, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Adenosine Deaminase, RNA-Specific, B1 (ADARB1) (AA 1-741) antibody
ADARB1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Adenosine Deaminase, RNA-Specific, B1 (ADARB1) (N-Term) antibodyADARB1 适用: 人, 大鼠, 小鼠, 斑马鱼, Cow, 犬, 马, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Adenosine Deaminase, RNA-Specific, B1 (ADARB1) (Center) antibodyADARB1 适用: 人, 大鼠, 小鼠, 斑马鱼, 小鸡 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Adenosine Deaminase, RNA-Specific, B1 (ADARB1) (Internal Region) antibodyADARB1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenosine Deaminase, RNA-Specific, B1 (ADARB1) antibodyADARB1 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Adenosine Deaminase, RNA-Specific, B1 (ADARB1) (Internal Region) antibodyADARB1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adenosine Deaminase, RNA-Specific, B1 (ADARB1) (AA 40-89) antibodyADARB1 适用: 人, 大鼠, 小鼠, Cow, 豚鼠, Hamster, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Adenosine Deaminase, RNA-Specific, B1 (ADARB1) (N-Term) antibodyADARB1 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Adenosine Deaminase, RNA-Specific, B1 (ADARB1) antibodyADARB1 适用: 大鼠 WB, ICC 宿主: 绵羊 Polyclonal unconjugated
anti-Adenosine Deaminase, RNA-Specific, B1 (ADARB1) (AA 180-380) antibodyADARB1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- RED1 (ADARB1) (Adenosine Deaminase, RNA-Specific, B1 (ADARB1))
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别名
- ADARB1
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背景
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Description: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins, pre-mRNA splicing by altering splice site recognition sequences, RNA stability by changing sequences involved in nuclease recognition, genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication, and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis.
Gene: ADARB1
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分子量
- 80 kDa
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基因ID
- 104
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UniProt
- P78563
抗原
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