VRK2 抗体 (Internal Region)
Quick Overview for VRK2 抗体 (Internal Region) (ABIN6257548)
抗原
See all VRK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- VRK2 Antibody detects endogenous levels of total VRK2.
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预测反应
- Horse,Sheep
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human VRK2, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Vaccinia Related Kinase 2 (VRK2) (AA 260-360) antibody
VRK2 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 3B10 unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (AA 1-508) antibodyVRK2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (AA 317-472) antibodyVRK2 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (AA 1-508) antibodyVRK2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (AA 151-250) antibodyVRK2 适用: 小鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Vaccinia Related Kinase 2 (VRK2) (Internal Region) antibodyVerified VRK2 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- VRK2 (Vaccinia Related Kinase 2 (VRK2))
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别名
- VRK2
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背景
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Description: Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.
Gene: VRK2
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分子量
- 55 kDa
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基因ID
- 7444
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UniProt
- Q86Y07
抗原
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