TAO Kinase 1 (TAOK1) (Internal Region) 抗体
Quick Overview for TAO Kinase 1 (TAOK1) (Internal Region) 抗体 (ABIN6257515)
抗原
See all TAO Kinase 1 (TAOK1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- TAOK1 Antibody detects endogenous levels of total TAOK1.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human TAOK1, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-TAO Kinase 1 (TAOK1) (AA 892-1001) antibody
TAOK1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4E12 unconjugated
anti-TAO Kinase 1 (TAOK1) (AA 400-659) antibodyTAOK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 1 (TAOK1) (C-Term) antibodyTAOK1 适用: 人, 大鼠, 小鼠, 猴, Cow, 犬, 马, Pig, 非洲爪蟾, Bat, Hamster, 兔, 小鸡 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 1 (TAOK1) (AA 431-480) antibodyTAOK1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 1 (TAOK1) (Internal Region) antibodyTAOK1 适用: 人, 猴 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TAO Kinase 1 (TAOK1) (C-Term) antibodyTAOK1 适用: 人, 大鼠, 小鼠, 猴, 非洲爪蟾 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- TAO Kinase 1 (TAOK1)
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别名
- TAOK1
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背景
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Description: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
Gene: TAOK1
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分子量
- 120 kDa
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基因ID
- 57551
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UniProt
- Q7L7X3
抗原
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