Sorting Nexin 1 抗体 (Internal Region)
Quick Overview for Sorting Nexin 1 抗体 (Internal Region) (ABIN6257498)
抗原
See all Sorting Nexin 1 (SNX1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- SNX1 Antibody detects endogenous levels of total SNX1.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human SNX1, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Sorting Nexin 1 (SNX1) (AA 166-275) antibody
SNX1 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 6H1 unconjugated
anti-Sorting Nexin 1 (SNX1) (AA 1-522) antibodySNX1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Sorting Nexin 1 (SNX1) (Internal Region) antibodyVerified SNX1 适用: 人 WB, ELISA, IHC, ICC 宿主: 山羊 Polyclonal unconjugated
anti-Sorting Nexin 1 (SNX1) (AA 1-150) antibodySNX1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 1 (SNX1) (AA 1-250) antibodySNX1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 1 (SNX1) (AA 1-522) antibodySNX1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 1 (SNX1) (AA 401-522) antibodySNX1 适用: 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 1 (SNX1) (AA 124-201) antibodySNX1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 1 (SNX1) antibodySNX1 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sorting Nexin 1 (SNX1) (Internal Region) antibodySNX1 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- Sorting Nexin 1 (SNX1)
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别名
- SNX1
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背景
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Description: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation, the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498).
Gene: SNX1
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分子量
- 59 kDa
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基因ID
- 6642
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UniProt
- Q13596
抗原
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